Skunk #1, remains one of the most famous strains of all time, born three decades ago in Holland, where breeders crossed multiple strains from South and Central America, Thailand, and Afghanistan. The result became a staple in itself and spawned countless hybrids containing its genes. This is an indica-dominant strain best used late in the day. Though it comes with a head buzz that belies its indica genes, Skunk #1 also provides deep-body relaxation. The head high is energetic and creative, while the body high is peaceful and soothing. It can be used to treat anxiety and other mental disorders, as well as chronic pain, headaches, and lack of appetite.